Genetherapy restores dim-light vision in dogs with a congenital form of night blindness Penn PNASNews
Dogs with CSNB that received a single injection of the gene therapy began to express the healthy LRIT3 protein in their retinas and were able to ably navigate a maze in dim light. The treatment also appears lasting, with a sustained therapeutic effect lasting a year or longer.
In the earlier work, the Penn Vet team, working in collaboration with groups from Japan, Germany, and the United States, discovered a population of dogs with CSNB and determined that mutations in thegene were responsible for the dogs' night vision impairment. The same gene has been implicated in certain cases of human CSNB as well.
"We've stepped into the no-man's land of the retina with this gene therapy," says William A. Beltran, a coauthor and professor at Penn Vet."This opens the door to treating other diseases that impact the ON bipolar cells."
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