As the days get shorter and chillier in the northern hemisphere, those who choose to work out in the mornings might find it harder to get up and running. A new study identifies a protein that, when missing, makes exercising in the cold that much harder--that is, at least in fruit flies.
As the days get shorter and chillier in the northern hemisphere, those who choose to work out in the mornings might find it harder to get up and running. A new study in PNAS identifies a protein that, when missing, makes exercising in the cold that much harder -- that is, at least in fruit flies.
They were particularly interested in a physiological process called autophagy wherein damaged parts of cells are removed from the body. In screening the fly genome, they found a candidate for regulating the critical housekeeping procedure., by tweaking the genetic makeup of some flies to overactivate autophagy in their eyes. Flies with too much autophagy had massive cell death leading to visible degeneration of the eye. Inactivatinggene is involved in the autophagy process.
Working with Dr. Robert Wessells team at Wayne State University who developed a novel way to train fruit flies, the investigators used a sort of fly cliff climber that capitalizes on the insect's instinct to climb upward out of a test tube.gene had impaired exercise endurance, and lacked the improvement typically seen after training. Furthermore, irisin in mammals is known to upregulate thermogenic processes, which is critical for cold resistance.
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Gene links exercise endurance, cold tolerance, and cellular maintenance in fliesAs the days get shorter and chillier in the northern hemisphere, those who choose to work out in the mornings might find it harder to get up and running. A study in PNAS identifies a protein that, when missing, makes exercising in the cold that much harder—that is, at least in fruit flies.
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